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Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 166-174 doi: 10.1007/s11684-014-0334-2

Abstract:

Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and isMorbidity and mortality are decreased with the successful treatment of chronic HCV infection.

Keywords： direct-acting antiviral (DAA)     nucleotide polymerase inhibitors     protease inhibitors    

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Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract:

Chronic hepatitis B is a major health burden worldwide.progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronichepatitis B.On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis

Keywords： chronic hepatitis B     therapeutic     antigen-antibody complexes     DNA     vaccine    

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Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 135-144 doi: 10.1007/s11684-014-0331-5

Abstract:

Chronic hepatitis B is a major health problem in China.The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infectionThe most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in westernprovinces are genotypes D and C/D hybrid.Chronic hepatitis B poses a heavy burden to the society in China.

Keywords： chronic hepatitis B     epidemiology     prevention     treatment    

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Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 271-276 doi: 10.1007/s11684-009-0054-1

Abstract: The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels duringthe course and the progression to cirrhosis with chronic hepatitis B.A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followedThe results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitisProgression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up

Keywords： hepatitis B     chronic     viral load     liver cirrhosis    

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New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 129-134 doi: 10.1007/s11684-014-0339-x

Abstract:

Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormousMechanisms responsible for chronic HBV infection remain poorly understood.Natural course of chronic HBV infection is conventionally viewed as an uninterrupted process that ismutant becomes predominant in the viral population following elimination of the wild-type virus in duck hepatitisand reinfection, and such cycles prolong the chronic HBV infection course.

Keywords： hepatitis B virus     chronic HBV infection     natural course     hepatitis B     seroconversion    

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: reported in COVID-19 patients, the association of liver injury caused by specific subtype especially chronichepatitis B (CHB) with COVID-19 has not been elucidated.

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract:

Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitisIn this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the lifeIn contrast to hepatitis B surface antigen (HBsAg) that can originate from either the cccDNA or the integratedimplicated as a “para-functional cure,” a status nearly close to the functional cure of chronichepatitis B, to distinguish the “functional cure” characterized as serum HBsAg loss with

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 250-253 doi: 10.1007/s11684-014-0333-3

Abstract:

The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively.The patient has suffered from hepatitis B for 30 years.His liver function deteriorated, yielding Child-Pugh grade C and reaching a model for end-stage liverComprehensive treatments included effective inhibition of hepatitis B virus replication and intensive

Keywords： acute-on-chronic liver failure     submassive necrosis     viral hepatitis B     esophageal variceal bleeding     liver    

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Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 658-666 doi: 10.1007/s11684-019-0707-7

Abstract: elevated α fetoprotein (AFP), but data on how these treatments affect elevated AFP in patients with chronichepatitis C (CHC) remain insufficient.

Keywords： chronic hepatitis C     α fetoprotein     direct acting antiviral treatment     cirrhosis    

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Current hepatitis B treatment guidelines and future research directions

Jonathan Skupsky,Ke-Qin Hu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 145-157 doi: 10.1007/s11684-014-0335-1

Abstract:

Hepatitis B virus (HBV) infection causes a tremendous clinical burden across the world with more than

Keywords： chronic hepatitis B     HBV treatment guidelines     APASL guidelines     EASL guidelines     AASLD guidelines    

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MicroRNAs and hepatitis viruses

Gang LI MD , Xiaojia XIONG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 265-270 doi: 10.1007/s11684-009-0055-0

Abstract: years, investigators gradually brought the concept of miRNA into studies of viral infection, including hepatitisThe hepatitis B and C viruses are common causes of liver disease worldwide.It is very difficult to cure chronic hepatitis due to drug resistance during antivirus therapy.Elucidating the mechanisms of virus-host interactions in hepatitis B and C is very important in diagnosisThis article reviews the current knowledge of viral hepatitis (B and C type) at the level of miRNA and

Keywords： microRNA     hepatitis B virus     hepatitis C virus    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitisB virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholic    

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Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis Article

Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang

Engineering 2023, Volume 26, Issue 7,   Pages 151-158 doi: 10.1016/j.eng.2023.03.008

Abstract: serum N-glycomic-derived models in diagnosing significant liver fibrosis and cirrhosis in 285 chronichepatitis B (CHB) patients with normal (< 40 IU·L–1) alanine aminotransferase

Keywords： Liver fibrosis     Chronic hepatitis B     Serum N-glycan     N-glycan model     Alanine aminotransferase    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: In patients with chronic renal failure, whether they have had hemodialysis or not, the specificity ofIt has been recently shown that some tumor markers are higher in patients with chronic kidney diseaseThe 232 non-dialysis patients with CKD and 37 chronic uremic patients treated with maintenance hemodialysis

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking

Xuqiang Wei, Baoyan Liu

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 767-775 doi: 10.1007/s11684-020-0785-6

Abstract: Most RCTs conclude that acupuncture procedures for chronic low back pain (CLBP) had no significant difference

Keywords： chronic low back pain     sham acupuncture     acupuncture     methodology     therapeutic evaluation    

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Title Author Date Type Operation

Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Journal Article

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Journal Article

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Journal Article

Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Journal Article

New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Journal Article

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Journal Article

Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Journal Article

Current hepatitis B treatment guidelines and future research directions

Jonathan Skupsky,Ke-Qin Hu

Journal Article

MicroRNAs and hepatitis viruses

Gang LI MD , Xiaojia XIONG MM ,

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis

Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking

Xuqiang Wei, Baoyan Liu

Journal Article